Why is glutathione conjugation important in drug metabolism
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Distribution, Biosynthesis, and Disease Associations Glutathione is found both intracellularly and in the extracellular matrix, with particularly high levels in: Lung tissue Brain tissue Liver tissue It is synthesized endogenously through a two-step enzymatic pathway involving -glutamylcysteine synthetase and glutathione synthetase
Results Increased severity of liver injury and mortality of mice with hepsin deficiency during the early period after acetaminophen exposure To investigate the potential physiological role of endogenous hepsin in the early response to APAP-induced liver injury, we analyzed hepsin expression in wild-type mouse liver lysates following APAP treatment using western blotting (Fig
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Mastrocola RRestivo F, Vercellinatto I, Danni O, Brignardello E, Aragno M, Boccuzzi G